Improved vaccines for the control of East Coast Fever: IPSR Innovation Profile

Brief
Published on

Abstract

The assessment of an experimental vaccine for the control of East Coast fever (ECF). Thelieria parva, the causative agent of ECF, is a killer parasite infecting cattle. The experimental vaccine is based on the use of nanoparticles to present and deliver p67C antigen. In future the vaccine will be developed by an animal health company and used by livestock keepers to significantly reduce morbidity and mortality in their cattle herds. The new technology will also validate the nanoparticle platform for the delivery of subunit vaccines for livestock.

Citation

Lacasta A., Nene, V., Lovel, J., King, N., Mwangi, T., ClinGlobal and GALVmed. 2022. Improved vaccines for the control of East Coast Fever: IPSR Innovation Profile. First edition, December 2022. Montpellier: CGIAR System Organization.

Authors

  • Lacasta, Anna
  • Nene, Vishvanath M.
  • Lovel, Jonathan
  • King, Neil
  • Mwangi, Thumbi

Related Publications

Novel CRISPR-Cas-powered pen-side test for East Coast fever

  • Muriuki, Robert
  • Ndichu, M.
  • Githigia, S.
  • Svitek, Nicholas

The hypervariable Tpr multigene family of Theileria parasites, defined by a conserved, membrane-associated, C-terminal domain, includes several copies with defined orthology between species

  • Palmateer, N.C.
  • Munro, James B.
  • Nagaraj, S.
  • Crabtree, J.
  • Pelle, Roger
  • Tallon, L.
  • Nene, Vishvanath M.
  • Bishop, Richard P.
  • Silva, J.C.

Benefits and financing options supporting the adoption of East Coast Fever Vaccine in Tanzania

  • Minz, S.
  • Teufel, Nils
  • Schlecht, E.

Rapport de la formation des formateurs sur la technique d’immunisation contre la theilériose par le Cocktail Muguga

  • Bimenyimana, Villard
  • Nyabongo, Lionel
  • Githaka, Naftaly W.

A single exon-encoded Theileria parva strain Muguga cysteine protease (ThpCP): Molecular modelling and characterization

  • Chauke, E.
  • Pelle, Roger
  • Coetzer, T.H.T.

Design and immunological evaluation of two-component protein nanoparticle vaccines for East Coast fever

  • Lacasta, Anna
  • Kim, H.C.
  • Kepl, E.
  • Gachogo, Rachael
  • Chege, Naomi
  • Ojuok, Rose
  • Muriuki, Charity
  • Mwalimu, Stephen
  • Touboul, G.
  • Stiber, A.
  • Poole, Elizabeth J.
  • Ndiwa, Nicholas N.
  • Fiala, B.
  • King, N.P.
  • Nene, Vishvanath M.